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Biochemical Mechanisms of Toxicity

University of Zagreb
Faculty of Science
Graduate studies in Biology/Toxicology

Lecturers:  Jasna  Kniewald  i  Elsa  Reiner

Programme:
Molecular and cellular aspects of toxicity . Mechanism of transport of xenobiotics through cell membranes. Binding to proteins. Biotransformation of toxic compounds. Binding to receptors. Factors influencing metabolism, deposition and excretion of xenobiotics. Specific examples: toxicity of metals, organophosphorus compounds, pesticides, organic solvents and effect of radiation.

Literature:
J.A. Timbrell: Principles of Biochemical Toxicology, Taylor & Francis Ltd., London (1992)

L.C. Lu: Basic Toxicology: Fundamentals, Target Organs and Risk Assesment, 2nd edition, Hemisphere Publishing Corporation, Washington (1991)

E. Giacobini (editor): Cholinesterases and Cholinesterase Inhibitors, Martin Dunitz Ltd., London (2000)